General Information
-
DRAMP ID
- DRAMP04381
-
Peptide Name
- PMM-2 (PMM analog)
-
Source
- Synthetic construct
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Family
- Not found
-
Gene
- Not found
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Sequence
- NWKKIASIGKEVLKAL
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli (MIC=21 µM);
- Gram-positive bacterium: Bacillus subtilis (MIC=46 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP04381_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C84H144N22O21
Absent Amino Acids
- CDFHMPQRTY
Common Amino Acids
- K
Mass
- 1798.2
PI
- 10
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 8
Net Charge
- +3
-
Boman Index
- -8.44
Hydrophobicity
- -0.019
Aliphatic Index
- 128.13
Half Life
-
- Mammalian:1.4 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 366.67
Polar Residues
- 3
DRAMP04381
Comments Information
Function
- Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
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Pubmed ID
- 18375018
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Reference
- Peptides. 2008 Jun;29(6):992-1003.
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Author
- Cerovský V, Slaninová J, Fucík V, Hulacová H, Borovicková L, Jezek R, Bednárová L.