General Information
-
DRAMP ID
- DRAMP04384
-
Peptide Name
- PMM-5 (PMM analog)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KIASIGKEVLKAL
-
Sequence Length
- 13
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli (MIC>100 µM);
- Gram-positive bacterium: Bacillus subtilis (MIC>100 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP04384.
Physicochemical Information
-
Formula
- C63H116N16O17
Absent Amino Acids
- CDFHMNPQRTWY
Common Amino Acids
- K
Mass
- 1369.71
PI
- 9.7
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 7
Net Charge
- +2
-
Boman Index
- 1.42
Hydrophobicity
- 0.615
Aliphatic Index
- 157.69
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP04384
Comments Information
Function
- Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification
- C-terminal amidation.
Literature Information
- ·Literature 1
-
Title
- New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
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Pubmed ID
- 18375018
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Reference
- Peptides. 2008 Jun;29(6):992-1003.
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Author
- Cerovský V, Slaninová J, Fucík V, Hulacová H, Borovicková L, Jezek R, Bednárová L.