General Information

    • DRAMP ID

    • DRAMP04392

    • Peptide Name

    • PMM-13 (PMM analog)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KNWKKIASIGKEVLKAL

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=12.5 µM);
      • Gram-positive bacterium: Bacillus subtilis (MIC=60 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04392 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C90H156N24O22

    • Absent Amino Acids

    • CDFHMPQRTY

    • Common Amino Acids

    • K

    • Mass

    • 1926.38

    • PI

    • 10.18

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -13.99

    • Hydrophobicity

    • -0.247

    • Aliphatic Index

    • 120.59

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 343.75

    • Polar Residues

    • 3

DRAMP04392

Comments Information

    • Function

    • Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.

    • Chemical modification

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.

    • Reference

    • Peptides. 2008 Jun;29(6):992-1003.

    • Author

    • Cerovský V, Slaninová J, Fucík V, Hulacová H, Borovicková L, Jezek R, Bednárová L.