General Information

    • DRAMP ID

    • DRAMP04458

    • Peptide Name

    • Defensin A

    • Source

    • Rhodnius prolixus (Triatomid bug)

    • Family

    • Not found

    • Gene

    • DEFA

    • Sequence

    • MKCILSLVTLFLVAVLVHSHPAEWNTHQQLDDALWEPAGEVTEEHVARLKRATCDLFSFRSKWVTPNHAACAAHCLLRGNRGGRCKGTICHCRK

    • Sequence Length

    • 94

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04458 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C463H734N142O126S8

    • Absent Amino Acids

    • Y

    • Common Amino Acids

    • LA

    • Mass

    • 10562.28

    • PI

    • 8.8

    • Basic Residues

    • 19

    • Acidic Residues

    • 8

    • Hydrophobic Residues

    • 36

    • Net Charge

    • +11

    • Boman Index

    • -142.76

    • Hydrophobicity

    • -0.104

    • Aliphatic Index

    • 86.17

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 16875

    • Absorbance 280nm

    • 181.45

    • Polar Residues

    • 25

DRAMP04458

DRAMP04458 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease.

    • Reference

    • Insect Biochem Mol Biol. 2003 Apr;33(4):439-447.

    • Author

    • Lopez L, Morales G, Ursic R, Wolff M, Lowenberger C.