General Information

    • DRAMP ID

    • DRAMP04530

    • Peptide Name

    • Urechistachykinins I (UI)

    • Source

    • Urechis unicinctus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LRQSQFVGSR

    • Sequence Length

    • 10

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.18570895] Gram-negative bacteria: Escherichia coli O-157 (MIC=10.6μM), Pseudomonas aeruginosa (MIC=21.3μM), Vibrio vulnificus (MIC=42.5μM) ;
      • Gram-positive bacteria: Streptococcus mutans(MIC=21.3μM), Staphylococcus aureus (MIC=42.5μM),Enterococcus faecium (MIC=21.3μM) ;
      • Fungi: Candida albicans (MIC=42.5μM), Trichosporon beigelii (MIC=21.3μM), Malassezia furfur (MIC=42.5μM).

    • Hemolytic Activity

      • [Ref.18570895] Has no hemolytic activities against human erythrocyte cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04530 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04530.

Physicochemical Information

    • Formula

    • C50H84N18O15

    • Absent Amino Acids

    • ACDEHIKMNPTWY

    • Common Amino Acids

    • QRS

    • Mass

    • 1177.33

    • PI

    • 12

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -34.84

    • Hydrophobicity

    • -0.72

    • Aliphatic Index

    • 68

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP04530

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Antifungal. Has no hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial effect and membrane-active mechanism of Urechistachykinins, neuropeptides derived from Urechis unicinctus.

    • Reference

    • FEBS Lett. 2008 Jul 9;582(16):2463-2466.

    • Author

    • Sung WS, Park SH, Lee DG.