General Information

    • DRAMP ID

    • DRAMP04532

    • Peptide Name

    • Myxinidin (Hagfish, animals)

    • Source

    • Myxine glutinosa (Atlantic hagfish)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIHDILKYGKPS

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19330556] Gram-negative bacteria: Escherichia coli D31 (MBC=2.0 μg/ml), Salmonella enterica serovar Typhimurium C610 (MBC=2.5 μg/mL), Pseudomonas aeruginosa Z61 (MBC=7.0μg/ml), Pseudomonas aeruginosa K799 (MBC=10.0 μg/ml), Aeromonas salmonicida sub sp. salmonicida A449 (MBC=2.0 μg/ml), Listonella anguillarum 02-11 (MBC=1.0 μg/ml), Yersinia ruckeri 96-4 (MBC=2.0 μg/ml);
      • Gram-positive bacterium: Staphylococcus epidermis C621(MBC=8.5 μg/ml);
      • Yeast: Candida albicans C627 (MBC=10.0 μg/ml).

    • Hemolytic Activity

      • [Ref.19330556] Non-hemolytic activity against rabbit red blood cells at concentrations 50-fold higher than its antimicrobial activity.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04532 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04532.

Physicochemical Information

    • Formula

    • C61H98N16O17

    • Absent Amino Acids

    • ACEFMNQRTVW

    • Common Amino Acids

    • GIK

    • Mass

    • 1327.55

    • PI

    • 8.51

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -11.38

    • Hydrophobicity

    • -0.517

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 4

DRAMP04532

Comments Information

    • Function

    • Myxinidin showed activity against a broad range of bacteria and yeast pathogens at minimum bactericidal concentration (MBC) ranging from 1.0 to 10.0

Literature Information

  • ·Literature 1

    • Title

    • Myxinidin, a novel antimicrobial peptide from the epidermal mucus of hagfish, Myxine glutinosa L.

    • Reference

    • Mar Biotechnol (NY). 2009 Nov-Dec;11(6):748-757.

    • Author

    • Subramanian S, Ross NW, MacKinnon SL.