General Information

    • DRAMP ID

    • DRAMP04533

    • Peptide Name

    • P-113D

    • Source

    • Homo sapiens

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AKRHHGYKRKFH

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04533 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04533.

Physicochemical Information

    • Formula

    • C71H109N27O14

    • Absent Amino Acids

    • CDEILMNPQSTVW

    • Common Amino Acids

    • HK

    • Mass

    • 1564.82

    • PI

    • 11.17

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +8

    • Boman Index

    • -54.88

    • Hydrophobicity

    • -2.283

    • Aliphatic Index

    • 8.33

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 2

DRAMP04533

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • P-113D, an Antimicrobial Peptide Active against Pseudomonas aeruginosa, Retains Activity in the Presence of putum from Cystic Fibrosis Patients.

    • Reference

    • Antimicrob Agents Chemother. 2001 Dec;45(12):3437-3444.

    • Author

    • Sajjan US, Tran LT, Sole N, Rovaldi C, Akiyama A, Friden PM, Forstner JF, Rothstein DM.