General Information

    • DRAMP ID

    • DRAMP04546

    • Peptide Name

    • Limnonectin-1Fb (Frogs, amphibians, animals)

    • Source

    • Limnonectes fujianensis (Fujian large-headed frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SFHVFPPWMCKSLKKC

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=70 µM)

    • Hemolytic Activity

      • [Ref.21396976] It exhibits no hemolytic activity at a concentration of up to 160 μM.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization(Cys10 and Cys16).

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys10 and Cys16.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04546 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04546.

Physicochemical Information

    • Formula

    • C91H136N22O19S3

    • Absent Amino Acids

    • ADEGINQRTY

    • Common Amino Acids

    • K

    • Mass

    • 1938.4

    • PI

    • 9.39

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +4

    • Boman Index

    • -5.95

    • Hydrophobicity

    • -0.006

    • Aliphatic Index

    • 42.5

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 375

    • Polar Residues

    • 4

DRAMP04546

Comments Information

    • Function

    • Possesses relatively potent growth inhibitory activity against the Gram-negative bacterium E. coli. Ineffective against the Gram-positive bacterium S. aureus and the potentially pathogenic yeast C. albicans at concentrations up to 160 µM.

Literature Information

  • ·Literature 1

    • Title

    • Limnonectins: A new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis).

    • Reference

    • Biochimie. 2011 Jun;93(6):981-987.

    • Author

    • Wu Y, Wang L, Zhou M, Ma C, Chen X, Bai B, Chen T, Shaw C.