General Information

    • DRAMP ID

    • DRAMP04640

    • Peptide Name

    • PGLa-AN2

    • Source

    • Xenopus andrei

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GMASKAGSVLGKLAKVAIGAL

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: E. coli (MIC=25 µM);
      • Gram-positive bacterium: S. aureus (MIC=100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04640 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04640.

Physicochemical Information

    • Formula

    • C86H156N24O24S

    • Absent Amino Acids

    • CDEFHNPQRTWY

    • Common Amino Acids

    • A

    • Mass

    • 1942.39

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 19.47

    • Hydrophobicity

    • 0.967

    • Aliphatic Index

    • 125.71

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP04640

DRAMP04640 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Genome duplications within the Xenopodinae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions.

    • Reference

    • Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):206-212.

    • Author

    • Mechkarska M, Eman A, Coquet L, Jérôme L, Jouenne T, Vaudry H, King JD, Takada K, Conlon JM.