General Information

    • DRAMP ID

    • DRAMP04654

    • Peptide Name

    • H-0, Hymenochirin-1B

    • Source

    • Hymenochirus boettgeri (Congo dwarf clawed frog)

    • Family

    • Unknown

    • Gene

    • Not found

    • Sequence

    • IKLSPETKDNLKKVLKGAIKGAIAVAKMV

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Experimental evidence at transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • [Ref.30789695] Cancer cell lines: A549 (IC50 = 15.22 ± 0.21 μM), HCT116 (IC50 = 12.76 ± 0.43 μM), HepG2 (IC50 = 8.07 ± 0.21 μM)

    • Hemolytic Activity

      • [Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25.0μM

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • α-helical (most likely)

    • Structure Description

    • No detailed structure description found.

    • Helical Wheel Diagram

    • DRAMP04654 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C139H251N37O37S

    • Absent Amino Acids

    • CFHQRWY

    • Common Amino Acids

    • K

    • Mass

    • 3064.81

    • PI

    • 10.13

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +5

    • Boman Index

    • -13.88

    • Hydrophobicity

    • 0.169

    • Aliphatic Index

    • 124.48

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP04654

DRAMP04654 chydropathy plot

Comments Information

    • Function

    • Antimicrobial, Anticancer, Immunomodulatory and Antidiabetic activity.

    • As a cationic, amphipathic, α-helical, 29-residue,host defense peptide, Hymenochirin-1B is the predominant pharmacological active component of four hymenochirins, which showed a wide range of biological activities, such as antimicrobial, anticancer, immunomodulatory, and antidiabetic activities. Surprisingly, we don't find the entry introducing Hymenochirin-1B in UniProt (2021-3-29).

Literature Information

  • ·Literature 1

    • Title

    • Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy

    • Reference

    • ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.

    • Author

    • Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao