General Information

    • DRAMP ID

    • DRAMP04663

    • Peptide Name

    • HPA3NT3-A1 (HPA3NT3 peptide analogs)

    • Source

    • Helicobacter pylori

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AKRLKKLAKKIWKWL

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=16 μM), Listeria monocytogenes(MIC=16 μM), Staphylococcus epidermidis(MIC=8 μM), Bacillus subtilis(MIC=8 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=32 μM), Pseudomonas aeruginosa(MIC=32 μM), Primula vulgaris(MIC=8-16 μM), Salmonella typhimurium(MIC=8 μM);
      • Fungi : Candida albicans(MIC=16 μM), Trichosporon beigelii(MIC>128 μM), Aspergillus awamori(MIC=64 μM), Aspergillus flavus(MIC=64 μM), Aspergillus fumigatus(MIC=16 μM), Aspergillus parasiticus(MIC=16 μM)

    • Hemolytic Activity

      • [Ref.22982494] 20.9% hemolysis at 250 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04663 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04663.

Physicochemical Information

    • Formula

    • C94H160N26O16

    • Absent Amino Acids

    • CDEFGHMNPQSTVY

    • Common Amino Acids

    • K

    • Mass

    • 1910.47

    • PI

    • 11.43

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +7

    • Boman Index

    • -20.26

    • Hydrophobicity

    • -0.68

    • Aliphatic Index

    • 117.33

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 785.71

    • Polar Residues

    • 0

DRAMP04663

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.

    • Reference

    • Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005

    • Author

    • Lee JK, Park SC, Hahm KS, Park Y.