General Information

    • DRAMP ID

    • DRAMP04673

    • Peptide Name

    • Alamethicin (ALM; fungi)

    • Source

    • Trichoderma viride

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PAAAAQAVAGLAPVAAEQ

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Antiparasitic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • The molecular conformation of the three crystallographically independent molecules is largely alpha-helical with a bend in the helix axis at an internal proline residue. The helix structure is highly amphipathic as most of the solvent-accessible polar atoms lie on a narrow strip of surface parallel to the helix axis.(Ref.2)

    • Helical Wheel Diagram

    • DRAMP04673 helical wheel diagram

    • PDB ID

    • 1AMT resolved by X-ray.
  • 1AMT-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP04673.

Physicochemical Information

    • Formula

    • C70H116N20O23

    • Absent Amino Acids

    • CDFHIKMNRSTWY

    • Common Amino Acids

    • A

    • Mass

    • 1605.81

    • PI

    • 4

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • -1

    • Boman Index

    • 12.34

    • Hydrophobicity

    • 0.794

    • Aliphatic Index

    • 103.89

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP04673

DRAMP04673 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Polypeptide anti-bacterial agent isolated from Trichoderma viride.

    • Reference

    • Experientia, 1967; 23: 85-86.

    • Author

    • Meyer CE, Reusser F.
  • ·Literature 2

    • Title

    • A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution.

    • Reference

    • Nature. 1982 Nov 25;300(5890):325-330.

    • Author

    • Fox RO Jr, Richards FM.