General Information

    • DRAMP ID

    • DRAMP04685

    • Peptide Name

    • Cysteine proteinase inhibitor 1 (KCPI1; Phytocystatin; Plant defensin)

    • Source

    • Actinidia chinensis (Kiwi) (Yangtao)

    • Family

    • Belongs to the cystatin family (Phytocystatin subfamily )

    • Gene

    • Not found

    • Sequence

    • VAAGGWRPIESLNSAEVQDV

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Not found

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • IgE

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04685 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04685.

Physicochemical Information

    • Formula

    • C91H144N26O31

    • Absent Amino Acids

    • CFHKMTY

    • Common Amino Acids

    • AV

    • Mass

    • 2098.3

    • PI

    • 4.14

    • Basic Residues

    • 1

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 9

    • Net Charge

    • -2

    • Boman Index

    • -2464

    • Hydrophobicity

    • -0.03

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 289.47

    • Polar Residues

    • 5

DRAMP04685

DRAMP04685 chydropathy plot

Comments Information

    • Function

    • Specific inhibitor of papain family cysteine proteinases (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of phytocystatins from kiwifruit cortex and seeds.

    • Reference

    • Phytochemistry. 2004 Jan;65(1):19-30.

    • Author

    • Rassam M, Laing WA.
  • ·Literature 2

    • Title

    • IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries.

    • Reference

    • J Allergy Clin Immunol. 2004 Nov;114(5):1169-1175.

    • Author

    • Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C.