General Information

    • DRAMP ID

    • DRAMP04695

    • Peptide Name

    • Dioicin-1 (Ribosome-inactivating protein; rRNA N-glycosidase; Plant defense)

    • Source

    • Phytolacca dioica (Bella sombra tree) (Phytolacca arborea)

    • Family

    • Belongs to the ribosome-inactivating protein family (Type 1 RIP subfamily)

    • Gene

    • Not found

    • Sequence

    • ANIVFDVESATTGTYSTFLTSF

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Toxin

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04695 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04695.

Physicochemical Information

    • Formula

    • C108H159N23O37

    • Absent Amino Acids

    • CHKMPQRW

    • Common Amino Acids

    • T

    • Mass

    • 2371.58

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 9

    • Net Charge

    • -2

    • Boman Index

    • -1394

    • Hydrophobicity

    • 0.482

    • Aliphatic Index

    • 70.91

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 70.95

    • Polar Residues

    • 11

DRAMP04695

DRAMP04695 chydropathy plot

Comments Information

    • Function

    • Nicks pBR322 dsDNA. Has adenine polynucleotide glycosidase activity on herring sperm ssDNA.

Literature Information

  • ·Literature 1

    • Title

    • Type 1 ribosome-inactivating proteins from Phytolacca dioica L. leaves: differential seasonal and age expression, and cellular localization.

    • Reference

    • Planta. 2008 Nov;228(6):963-975.

    • Author

    • Parente A, Conforto B, Di Maro A, Chambery A, De Luca P, Bolognesi A, Iriti M, Faoro F.