General Information

    • DRAMP ID

    • DRAMP04696

    • Peptide Name

    • Ribosome-inactivating protein momorcochin-S (rRNA N-glycosidase; Plant defense)

    • Source

    • Momordica cochinchinensis (Spiny bitter cucumber)

    • Family

    • Belongs to the ribosome-inactivating protein family (Type 1 RIP subfamily)

    • Gene

    • Not found

    • Sequence

    • DVTFSLLGANTKSYAAFITNFRKDVASEKK

    • Sequence Length

    • 30

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Toxin

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04696 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04696.

Physicochemical Information

    • Formula

    • C150H237N39O46

    • Absent Amino Acids

    • CHMPQW

    • Common Amino Acids

    • AK

    • Mass

    • 3322.77

    • PI

    • 9.4

    • Basic Residues

    • 5

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -5274

    • Hydrophobicity

    • -0.257

    • Aliphatic Index

    • 71.67

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 51.38

    • Polar Residues

    • 10

DRAMP04696

DRAMP04696 chydropathy plot

Comments Information

    • Function

    • Inactivates eukaryotic 60S ribosomal subunits.

    • PTM

    • Glycosylated.

Literature Information

  • ·Literature 1

    • Title

    • Purification and properties of a new ribosome-inactivating protein with RNA N-glycosidase activity suitable for immunotoxin preparation from the seeds of Momordica cochinchinensis.

    • Reference

    • Biochim Biophys Acta. 1989 Dec 8;993(2-3):287-292.

    • Author

    • Bolognesi A, Barbieri L, Carnicelli D, Abbondanza A, Cenini P, Falasca AI, Dinota A, Stirpe F.