General Information
-
DRAMP ID
- DRAMP04697
-
Peptide Name
- Ribosome-inactivating protein momorgrosvin (rRNA N-glycosidase; Plant defense)
-
Source
- Siraitia grosvenorii (Monk's fruit) (Luo han guo)
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Family
- Belongs to the ribosome-inactivating protein family (Type 1 RIP subfamily)
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Gene
- Not found
-
Sequence
- DVTFSMLGANGATYYQFF
-
Sequence Length
- 18
-
UniProt Entry
- P83323
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Toxin
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP04697.
Physicochemical Information
-
Formula
- C95H130N20O28S
Absent Amino Acids
- CEHIKPRW
Common Amino Acids
- F
Mass
- 2032.25
PI
- 3.8
Basic Residues
- 0
Acidic Residues
- 1
Hydrophobic Residues
- 7
Net Charge
- -1
-
Boman Index
- -397
Hydrophobicity
- 0.322
Aliphatic Index
- 48.89
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 2980
Absorbance 280nm
- 175.29
Polar Residues
- 8
DRAMP04697
Comments Information
Function
- Inhibits protein synthesis in the rabbit reticulocyte lysate system.
Catalytic activity
- Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
PTM
- Glycosylated.
Literature Information
- ·Literature 1
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Title
- Isolation and characterization of a new ribosome inactivating protein, momorgrosvin, from seeds of the monk's fruit Momordica grosvenorii.
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Pubmed ID
- 11205869
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Reference
- Life Sci. 2001 Jan 5;68(7):773-784.
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Author
- Tsang KY, Ng TB.