General Information

    • DRAMP ID

    • DRAMP04699

    • Peptide Name

    • Amphipathic peptide CT2 (VsCT2; Non-disulfide-bridged peptide 5.12, NDBP-5.12)

    • Source

    • Vaejovis subcristatus (Scorpion) (Thorellius subcristatus)

    • Family

    • Belongs to the scorpion NDBP 5 family

    • Gene

    • Not found

    • Sequence

    • FLKGIIDTVSKLF

    • Sequence Length

    • 13

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • [Swiss_Prot Entry I0DEB6]No antibacterial activity even at 50 µM

    • Hemolytic Activity

      • [Ref.22342498]5% hemolytic activity at 12.5 μM, 25% hemolytic activity at 25 μM, 80% hemolytic activity at 50 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04699 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04699.

Physicochemical Information

    • Formula

    • C352H573N87O102S2

    • Absent Amino Acids

    • CHPW

    • Common Amino Acids

    • L

    • Mass

    • 1480.81

    • PI

    • 8.59

    • Basic Residues

    • 8

    • Acidic Residues

    • 9

    • Hydrophobic Residues

    • 30

    • Net Charge

    • -1

    • Boman Index

    • -6514

    • Hydrophobicity

    • 0.257

    • Aliphatic Index

    • 128.97

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 44.48

    • Polar Residues

    • 14

DRAMP04699

Comments Information

    • Function

    • Amphipatic peptide that shows no antibacterial activity even at 50 µM but shows hemolytic activity against human erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.

    • Reference

    • Peptides. 2012 Apr;34(2):290-295.

    • Author

    • Ramírez-Carreto S, Quintero-Hernández V, Jiménez-Vargas JM, Corzo G, Possani LD, Becerril B, Ortiz E.