General Information
-
DRAMP ID
- DRAMP04702
-
Peptide Name
- 38 kDa autolysin (Beta-glycosidase; Peptidoglycan hydrolase)
-
Source
- Mycobacterium phlei
-
Family
- Not found
-
Gene
- lytA
-
Sequence
- VAVKATTTEEETEIPAK
-
Sequence Length
- 17
-
UniProt Entry
- P81528
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Toxin
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP04702.
Physicochemical Information
-
Formula
- C78H133N19O30
Absent Amino Acids
- CDFGHLMNQRSWY
Common Amino Acids
- ET
Mass
- 1817.02
PI
- 4.49
Basic Residues
- 2
Acidic Residues
- 4
Hydrophobic Residues
- 6
Net Charge
- -2
-
Boman Index
- -3019
Hydrophobicity
- -0.465
Aliphatic Index
- 74.71
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP04702
Comments Information
Function
- Hydrolyzes the cell walls of mycobacteria. May play an important role in cell wall growth and cell separation.
Biophysicochemical properties
- pH dependence (Optimum pH is 7.5).
PTM
- The N-terminus is blocked (Probable).
Literature Information
- ·Literature 1
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Title
- Partial characterization of a major autolysin from Mycobacterium phlei.
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Pubmed ID
- 10206696
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Reference
- Microbiology. 1999 Jan;145 ( Pt 1):169-176.
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Author
- Li ZS, Beveridge TJ, Betts J, Clarke AJ.