General Information
-
DRAMP ID
- DRAMP04703
-
Peptide Name
- Crotamine CRO1
-
Source
- Crotalus durissus terrificus (South American rattlesnake)
-
Family
- Belongs to the crotamine-myotoxin family
-
Gene
- CRO1
-
Sequence
- YKQCHKKGGHCFPKEKICIPPSSDFGKMDCRWRWKCCKKGSGK
-
Sequence Length
- 43
-
UniProt Entry
- O57540
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Toxin
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP04703.
Physicochemical Information
-
Formula
- C346H530N90O82S8
Absent Amino Acids
- TV
Common Amino Acids
- K
Mass
- 5017.98
PI
- 9.61
Basic Residues
- 15
Acidic Residues
- 4
Hydrophobic Residues
- 20
Net Charge
- +11
-
Boman Index
- -6706
Hydrophobicity
- -0.283
Aliphatic Index
- 58.62
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 14355
Absorbance 280nm
- 224.3
Polar Residues
- 19
DRAMP04703
Comments Information
Function
- Cationic peptide that possess multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage- gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
-
Title
- Nucleotide sequence of crotamine isoform precursors from a single South American rattlesnake (Crotalus durissus terrificus).
-
Pubmed ID
- 10484745
-
Reference
- Toxicon. 1999 Jul;37(7):973-984.
-
Author
- Rádis-Baptista G, Oguiura N, Hayashi MA, Camargo ME, Grego KF, Oliveira EB, Yamane T.