General Information
-
DRAMP ID
- DRAMP04706
-
Peptide Name
- Myotoxin-1 (Myotoxin I)
-
Source
- Crotalus oreganus concolor (Midget faded rattlesnake) (Crotalusviridis concolor)
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Family
- Belongs to the crotamine-myotoxin family
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Gene
- Not found
-
Sequence
- YKRCHKKEGHCFPKTVICLPPSSDFGKMDCRWKWKCCKKGSVN
-
Sequence Length
- 43
-
UniProt Entry
- P12028
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Toxin
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP04706_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C223H349N65O56S7
Absent Amino Acids
- AQ
Common Amino Acids
- K
Mass
- 5061.05
PI
- 9.51
Basic Residues
- 13
Acidic Residues
- 3
Hydrophobic Residues
- 8
Net Charge
- +10
-
Boman Index
- -9152
Hydrophobicity
- -0.872
Aliphatic Index
- 31.63
Half Life
-
- Mammalian:2.8 hour
- Yeast:10 min
- E.coli:2 min
Extinction Coefficient Cystines
- 12865
Absorbance 280nm
- 306.31
Polar Residues
- 15
DRAMP04706
Comments Information
Function
- Cationic peptide that possess multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage- gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
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Title
- Amino acid sequences of myotoxins from Crotalus viridis concolor venom.
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Pubmed ID
- 3629618
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Reference
- Toxicon. 1987;25(6):677-680.
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Author
- Bieber AL, McParland RH, Becker RR.