General Information
-
DRAMP ID
- DRAMP04709
-
Peptide Name
- Myotoxin-2 (Myotoxin II)
-
Source
- Crotalus oreganus concolor (Midget faded rattlesnake) (Crotalusviridis concolor)
-
Family
- Belongs to the crotamine-myotoxin family
-
Gene
- Not found
-
Sequence
- YKRCHKKGGHCFPKEKICTPPSSDFGKMDCRWKWKCCKKGSVN
-
Sequence Length
- 43
-
UniProt Entry
- P12029
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Toxin
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP04709.
Physicochemical Information
-
Formula
- C220H344N66O56S7
Absent Amino Acids
- ALQ
Common Amino Acids
- K
Mass
- 5033.98
PI
- 9.61
Basic Residues
- 14
Acidic Residues
- 3
Hydrophobic Residues
- 6
Net Charge
- +11
-
Boman Index
- -10000
Hydrophobicity
- -1.158
Aliphatic Index
- 15.81
Half Life
-
- Mammalian:2.8 hour
- Yeast:10 min
- E.coli:2 min
Extinction Coefficient Cystines
- 12865
Absorbance 280nm
- 306.31
Polar Residues
- 16
DRAMP04709
Comments Information
Function
- Cationic peptide that possess multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage- gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
-
Title
- Amino acid sequences of myotoxins from Crotalus viridis concolor venom.
-
Pubmed ID
- 3629618
-
Reference
- Toxicon. 1987;25(6):677-680.
-
Author
- Bieber AL, McParland RH, Becker RR.