General Information
-
DRAMP ID
- DRAMP04711
-
Peptide Name
- Myotoxin-3 (Crotamine-3)
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Source
- Crotalus durissus terrificus (South American rattlesnake)
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Family
- Belongs to the crotamine-myotoxin family
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Gene
- Not found
-
Sequence
- YKRCHIKGGHCFPKGKICIPPSSDFGKMDCPWRRKCCKKGSG
-
Sequence Length
- 42
-
UniProt Entry
- P24333
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Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Toxin
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP04711.
Physicochemical Information
-
Formula
- C338H526N90O79S8
Absent Amino Acids
- QTV
Common Amino Acids
- K
Mass
- 4741.69
PI
- 9.7
Basic Residues
- 15
Acidic Residues
- 3
Hydrophobic Residues
- 20
Net Charge
- +12
-
Boman Index
- -6055
Hydrophobicity
- -0.132
Aliphatic Index
- 64.62
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 138.36
Polar Residues
- 20
DRAMP04711
Comments Information
Function
- Cationic peptide that possess multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage- gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
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Title
- Cloning and nucleotide sequences of crotamine genes.
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Pubmed ID
- 2389256
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Reference
- Toxicon. 1990;28(5):575-585.
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Author
- Smith LA, Schmidt JJ.