General Information
-
DRAMP ID
- DRAMP18100
-
Peptide Name
- Beta/delta-agatoxin-3 (Mu-2Aga_04; U3-agatoxin-Ao1c; U3-AGTX-Ao1c)
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Source
- Agelena orientalis (Spider)
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Family
- Belongs to the beta/delta-agatoxin family
-
Gene
- Not found
-
Sequence
- GCVGENQQCADWAGPHCCSGYYCTCRYFPKCICRKDS
-
Sequence Length
- 37
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UniProt Entry
- Q5Y4V6
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Insecticidal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18100.
Physicochemical Information
-
Formula
- C353H555N95O104S10
Absent Amino Acids
Common Amino Acids
- CGL
Mass
- 4153.72
PI
- 7.7
Basic Residues
- 8
Acidic Residues
- 8
Hydrophobic Residues
- 24
Net Charge
- 0
-
Boman Index
- -7211
Hydrophobicity
- 0.162
Aliphatic Index
- 82.88
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 10470
Absorbance 280nm
- 145.42
Polar Residues
- 26
DRAMP18100
Comments Information
Function
- Insecticidal neurotoxin that modulates the insect Nav channel (DmNaV1/tipE (para/tipE)) in a unique manner, with both the activation and inactivation processes being affected. The voltage dependence of activation is shifted toward more hyperpolarized potentials (analogous to site 4 toxins) and a non- inactivating persistent sodium current is induced (site 3-like action). Interestingly, both effects take place in a voltage- dependent manner, producing a bell-shaped curve between -80 and 0 mV. Compared to beta/delta-agatoxin-1 to -3, this toxin appears to affect the insect sodium channel only weakly.##Miscellaneous
Literature Information
- ·Literature 1
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Title
- A novel strategy for the identification of toxinlike structures inspider venoM.
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Pubmed ID
- 15688451
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Reference
- Proteins 59:131-140 (2005).
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Author
- Kozlov S. A., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R., Grishin E.V.
- ·Literature 2
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Title
- Unique bell-shaped voltage-dependent modulation of Na+ channel gatingby novel insect-selective toxins from the spider Agelena orientaliS.
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Pubmed ID
- 20385552
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Reference
- J. Biol. CheM. 285:18545-18554 (2010).
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Author
- Billen B., Vassilevski A., Nikolsky A., Debaveye S. , Tytgat J., Grishin E.