General Information

    • DRAMP ID

    • DRAMP18108

    • Peptide Name

    • Asteropin-A (Asteropine-A)

    • Source

    • Asteropus simplex (Marine sponge) (Stellettinopsis simplex)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • YCGLFGDLCTLDGTLACCIALELECIPLNDFVGICL

    • Sequence Length

    • 36

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • V. cholerae (Ki values of 340 nM), S. typhimurium (Ki values of 350 nM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18108 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18108.

Physicochemical Information

    • Formula

    • C169H267N37O51S6

    • Absent Amino Acids

    • HKMQRSW

    • Common Amino Acids

    • L

    • Mass

    • 3825.56

    • PI

    • 3.33

    • Basic Residues

    • 0

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 16

    • Net Charge

    • -5

    • Boman Index

    • 2748

    • Hydrophobicity

    • 1.261

    • Aliphatic Index

    • 132.78

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 53.29

    • Polar Residues

    • 14

DRAMP18108

DRAMP18108 chydropathy plot

Comments Information

    • Function

    • Sialidase inhibitor. Competitively inhibits bacterial sialidases, but not viral sialidaseS. Does not inhibit glycosidases or proteaseS. Has no antitumor activity.

Literature Information

  • ·Literature 1

    • Title

    • Asteropine A, a sialidase-inhibiting conotoxin-like peptide from themarine sponge Asteropus simplex.

    • Reference

    • CheM. Biol. 13:569-574 (2006).

    • Author

    • Takada K., Hamada T., Hirota H., Nakao Y., Matsunaga S. , van Soest R.W.M. , Fusetani N.