General Information

    • DRAMP ID

    • DRAMP18116

    • Peptide Name

    • U2-segestritoxin-Sf1b (U2-SGTX-Sf1b; F5.7; Toxin SFI 2)

    • Source

    • Segestria florentina (Tube-web spider) (Segestria gracilis)

    • Family

    • Belongs to the spider toxin SFI family

    • Gene

    • Not found

    • Sequence

    • QDFMKHLDKKTQTPKL

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Insecticidal

    • Target Organism

    • Heliothis virescens (LD50=7 μg/g)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18116 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18116.

Physicochemical Information

    • Formula

    • C213H330N62O66S10

    • Absent Amino Acids

    • FQ

    • Common Amino Acids

    • C

    • Mass

    • 1958.31

    • PI

    • 9.53

    • Basic Residues

    • 6

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • -6389

    • Hydrophobicity

    • -0.376

    • Aliphatic Index

    • 50.87

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8980

    • Absorbance 280nm

    • 199.56

    • Polar Residues

    • 21

DRAMP18116

Comments Information

    • Function

    • Causes flaccid paralysis followed by death when injected into Heliothis virescens larvae. Does not induce any toxic effects when injected intravenously into adult mice at a dose of 1.25 mg/kg body weight.

Literature Information

  • ·Literature 1

    • Title

    • Novel insecticidal toxins from the venom of the spider Segestriaflorentina.

    • Reference

    • Toxicon 40:125-130 (2002).

    • Author

    • Lipkin A., Kozlov S. , Nosyreva E., Blake A., Windass J.D., Grishin E.