General Information
-
DRAMP ID
- DRAMP18117
-
Peptide Name
- U2-segestritoxin-Sf1a (U2-SGTX-Sf1a; F5.6; Toxin SFI 1)
-
Source
- Segestria florentina (Tube-web spider) (Segestria gracilis)
-
Family
- Belongs to the spider toxin SFI family
-
Gene
- Not found
-
Sequence
- KECMTDGTVCYIHNHNDCCGSCLCSNGPIARPWEMMVGNCMCGPKA
-
Sequence Length
- 46
-
UniProt Entry
- P61095
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Insecticidal
-
Target Organism
- Heliothis virescens (LD50=10 μg/g)
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- 2MF3
-
Predicted Structure
- There is no predicted structure for DRAMP18117.
Physicochemical Information
-
Formula
- C201H316N60O64S12
Absent Amino Acids
- FQ
Common Amino Acids
- C
Mass
- 4981.8
PI
- 6.01
Basic Residues
- 5
Acidic Residues
- 4
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- -5191
Hydrophobicity
- -0.137
Aliphatic Index
- 42.39
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 7490
Absorbance 280nm
- 166.44
Polar Residues
- 22
DRAMP18117
Comments Information
Function
- Causes flaccid paralysis followed by death when injected into Heliothis virescens larvae. Does not induce any toxic effects when injected intravenously into adult mice at a dose of 1.5 mg/kg body weight. Orally active against larvae of the tomato moth (Laconobia oleracea), the rice brown planthopper (Nilaparvata lugens), and the peach-potato aphid (Myzus persicae) when fused to snowdrop lectin.
Literature Information
- ·Literature 1
-
Title
- Novel insecticidal toxins from the venom of the spider Segestriaflorentina.
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Pubmed ID
- 11689233
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Reference
- Toxicon 40:125-130 (2002).
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Author
- Lipkin A., Kozlov S. , Nosyreva E., Blake A., Windass J.D., Grishin E.
- ·Literature 2
-
Title
- Fusion proteins containing insect-specific toxins as pest controlagents: snowdrop lectin delivers fused insecticidal spider venom toxinto insect haemolymph following oral ingestion.
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Pubmed ID
- 15037094
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Reference
- J. Insect Physiol. 50:61-71 (2004).
-
Author
- Fitches E., Edwards M. G., Mee C. , Grishin E., Gatehouse A.M. , Edwards J.P., Gatehouse J.A.