General Information

    • DRAMP ID

    • DRAMP18118

    • Peptide Name

    • U2-segestritoxin-Sf1i (U2-SGTX-Sf1i; Toxin F5.5; Fragment)

    • Source

    • Segestria florentina (Tube-web spider) (Segestria gracilis)

    • Family

    • Belongs to the spider toxin SFI family

    • Gene

    • Not found

    • Sequence

    • AECMVDETVCYIHNHNNC

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Insecticidal

    • Target Organism

    • Heliothis virescens (LD50=4 μg/g)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18118 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18118.

Physicochemical Information

    • Formula

    • C84H127N25O30S4

    • Absent Amino Acids

    • FGKLPQRSW

    • Common Amino Acids

    • CN

    • Mass

    • 2095.32

    • PI

    • 4.63

    • Basic Residues

    • 2

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 4

    • Net Charge

    • -1

    • Boman Index

    • -3329

    • Hydrophobicity

    • -0.294

    • Aliphatic Index

    • 59.44

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 95

    • Polar Residues

    • 8

DRAMP18118

DRAMP18118 chydropathy plot

Comments Information

    • Function

    • Insecticidal toxin. Causes flaccid paralysis followed by death when injected into Heliothis virescens larvae. Does not induce any toxic effects when injected intravenously into adult mice at a dose of 1.1 mg/kg body weight.

Literature Information

  • ·Literature 1

    • Title

    • Novel insecticidal toxins from the venom of the spider Segestriaflorentina.

    • Reference

    • Toxicon 40:125-130 (2002).

    • Author

    • Lipkin A., Kozlov S. , Nosyreva E., Blake A., Windass J.D., Grishin E.