General Information
-
DRAMP ID
- DRAMP18122
-
Peptide Name
- Mu-agatoxin-Hc1a (Mu-AGTX-Hc1a; Curtatoxin-1; CT-I)
-
Source
- Hololena curta (Funnel-web spider) (Agelena curta)
-
Family
- Belongs to the beta/delta-agatoxin family
-
Gene
- Not found
-
Sequence
- SCVGEYGRCRSAYEDCCDGYYCNCSQPPYCLCRNNN
-
Sequence Length
- 36
-
UniProt Entry
- P15967
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Insecticidal
-
Target Organism
- A.domestica (LD50=20 μg/g)
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18122.
Physicochemical Information
-
Formula
- C165H242N50O58S8
Absent Amino Acids
- FHIKMTW
Common Amino Acids
- C
Mass
- 4110.52
PI
- 4.78
Basic Residues
- 3
Acidic Residues
- 4
Hydrophobic Residues
- 3
Net Charge
- -1
-
Boman Index
- -9499
Hydrophobicity
- -0.792
Aliphatic Index
- 21.67
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7950
Absorbance 280nm
- 227.14
Polar Residues
- 23
DRAMP18122
Comments Information
Function
- Insecticidal neurotoxin that induces irreversible neuromuscular blockade in the cricket A.domestica. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neuronS.
Literature Information
- ·Literature 1
-
Title
- CurtatoxinS. Neurotoxic insecticidal polypeptides isolated from thefunnel-web spider Hololena curta.
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Pubmed ID
- 2298738
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Reference
- J. Biol. CheM. 265:2054-2059 (1990).
-
Author
- Stapleton A., Blankenship D.T., Ackermann D.L., Chen T.-M. , Gorder G.W., Manley G.D., Palfreyman M. G., Coutant J.E., Cardin A.D.
- ·Literature 2
-
Title
- Agatoxins: ion channel specific toxins from the American funnel webspider, Agelenopsis aperta.
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Pubmed ID
- 15066410
-
Reference
- Toxicon 43:509-525 (2004).
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Author
- Adams M. E.