• DRAMP ID

    • DRAMP18130
    • Peptide Name

    • Antimicrobial peptide HsAp2
    • Source

    • Heterometrus spinifer (Asia giant forest scorpion) (Malaysian blackscorpion)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • SGTSEKERESERLLGVVNPLIKCFRSPCP
    • Sequence Length

    • 29
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.23000095]Gram-positive bacteria: Staphylococcus aureus AB 94004 (MIC=23.6μM), Bacillus magaterium AB 90008 (MIC=11.8μM), Bacillus thuringiensis AB 93100 (MIC=46.5μM);
      • Gram-negative bacteria: Salmonella enterica AB 2010185 (MIC=25.0μM), E. coli DH5 (MIC=51.2μM), E. coli JM109 (MIC=50.4μM), Enterobacter cloacae subsp. cloacae AB 2010162 (MIC=47.9μM), Klebsiella oxytoca AB 2010143 (MIC=50.5μM);
      • Fungi: Candida tropicalis AY 91009 (MIC=48.6μM).
    • Hemolytic Activity

      • [Ref.23000095]5% hemolytic activity at 0.8 μM, 35% hemolytic activity at 1.6 μM, 95% hemolytic activity at 3.2 μM, 100% hemolytic activity against human red blood cells.
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18130 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18130.
    • Formula

    • C369H629N107O106S6
    • Absent Amino Acids

    • DH
    • Common Amino Acids

    • ELRS
    • Mass

    • 3232.72
    • PI

    • 7.78
    • Basic Residues

    • 14
    • Acidic Residues

    • 8
    • Hydrophobic Residues

    • 24
    • Net Charge

    • +6
    • Boman Index

    • -10000
    • Hydrophobicity

    • -0.178
    • Aliphatic Index

    • 96.08
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7115
    • Absorbance 280nm

    • 97.47
    • Polar Residues

    • 20

DRAMP18130

DRAMP18130 chydropathy plot
    • Function

    • Possesses antimicrobial activity against both Gram- negative and Gram-positive bacteria, as well as against the fungus C. tropicaliS. Also possess a relatively high hemolytic activity (By similarity).
  • ·Literature 1
    • Title

    • A novel class of antimicrobial peptides from the scorpionHeterometrus spinifer.
    • Reference

    • Peptides 38:389-394 (2012).
    • Author

    • Nie Y., Zeng X.C. , Yang Y., Luo F., Luo X., Wu S. , Zhang L., Zhou J.