General Information

    • DRAMP ID

    • DRAMP18140

    • Peptide Name

    • VG16KRKP

    • Source

    • Synthetic construct

    • Family

    • Gene

    • Sequence

    • VARGWKRKCPLFGKGG

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative: E. coli (MIC=8 uM), X. campestris (MIC=10 uM), X. oryzae (MIC=15 uM);
      • Gram-positive: B. subtilis (MIC=50 uM);
      • Fungi: Candida albicans (MIC=2 uM), Cryptococcus grubii (MIC=5 uM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Structure Description

    • The solution-NMR structure of VG16KRKP in lipopolysaccharide features a folded conformation with a centrally located turn-type structure stabilized by aromatic-aromatic packing interactions with extended N- and C-termini.

    • Helical Wheel Diagram

    • DRAMP18140 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP18140.

Physicochemical Information

    • Formula

    • C80H130N26O17S

    • Absent Amino Acids

    • DEHIMNQSTY

    • Common Amino Acids

    • G

    • Mass

    • 1760.14

    • PI

    • 11.11

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +5

    • Boman Index

    • -2537

    • Hydrophobicity

    • -0.606

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 366.67

    • Polar Residues

    • 5

DRAMP18140

Comments Information

    • VG16KRKP is capable of inhibiting bacterial disease progression in plants.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control

    • Reference

    • Sci Rep. 2015 Jul 6;5:11951.

    • Author

    • Datta A, Ghosh A, Airoldi C, etal.