General Information

    • DRAMP ID

    • DRAMP18141

    • Peptide Name

    • Nephilakinin-3 (Nephilakinin-III)

    • Source

    • Nephila clavipes (Golden silk orbweaver)

    • Family

    • Belongs to the bradykinin-related peptide family

    • Gene

    • Not found

    • Sequence

    • PSPPGFSPFR

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Insecticidal

    • Target Organism

    • ED50=0.7μM;LD50=70±17pmoles/mg honeybee

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18141 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18141.

Physicochemical Information

    • Formula

    • C52H73N13O13

    • Absent Amino Acids

    • ACDEHIKLMNQTVWY

    • Common Amino Acids

    • P

    • Mass

    • 1088.23

    • PI

    • 10.18

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +1

    • Boman Index

    • -1482

    • Hydrophobicity

    • -0.73

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18141

Comments Information

    • Function

    • Causes constriction on isolated rat ileum preparations and relaxation on rat duodenum muscle preparations at amounts higher than bradykinin. Is a partial agonist bradykinin receptor B2 (BDKRB2). Has insecticidal propertieS. May be related to the predation of insects by the spider webS. ##Miscellaneous

Literature Information

  • ·Literature 1

    • Title

    • Multiple bradykinin-related peptides from the capture web of thespider Nephila clavipes (Araneae, Tetragnatidae).

    • Reference

    • Peptides 27:690-697 (2006).

    • Author

    • Volsi E.C. , Mendes M. A., Marques M. R., dos Santos L.D., Santos K.S. , de Souza B.M. , Babieri E.F., Palma M. S.