General Information

    • DRAMP ID

    • DRAMP18147

    • Peptide Name

    • Cytotoxin drCT-1 (drCT-I; Fragment)

    • Source

    • Daboia russelii (Russel's viper) (Vipera russelii)

    • Family

    • Belongs to the snake three-finger toxin family

    • Gene

    • Not found

    • Sequence

    • LKCNKLVPLFYKTCPAGKNL

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Anti-cancer, Cytotoxic

    • Target Organism

    • IC50=8.9 μg/ml for U937 and 6.7 μg/ml for K562

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18147 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18147.

Physicochemical Information

    • Formula

    • C104H172N26O25S2

    • Absent Amino Acids

    • DEHIMQRSW

    • Common Amino Acids

    • KL

    • Mass

    • 2250.79

    • PI

    • 9.6

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -618

    • Hydrophobicity

    • 0.04

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 85

    • Polar Residues

    • 7

DRAMP18147

DRAMP18147 chydropathy plot

Comments Information

    • Function

    • This three-finger cytotoxin has antiproliferative, cytotoxic and apoptotic activitieS. Both in vivo and in vitro experimental results suggests that this protein possess anticancer potential. Also shows neurotoxicity, cardiotoxicity and myotoxicity.

Literature Information

  • ·Literature 1

    • Title

    • A heat stable protein toxin (drCT-I) from the Indian Viper (Daboiarusselli russelli) venom having antiproliferative, cytotoxic andapoptotic activitieS.

    • Reference

    • Toxicon 49:46-56 (2007).

    • Author

    • Gomes A., Choudhury S. R., Saha A., Mishra R., Giri B., Biswas A.K., Debnath A., Gomes A.
  • ·Literature 2

    • Title

    • Purification, crystallization and preliminary X-ray structuralstudies of a 7.2 kDa cytotoxin isolated from the venom of Daboiarusselli russelli of the Viperidae family.

    • Reference

    • Acta Crystallogr. F 62:292-294 (2006).

    • Author

    • Choudhury S. R., Gomes A., Gomes A., Dattagupta J.K., Sen U.