• • DRAMP ID

  • DRAMP18185

• • Peptide Name

  • Jingdongin-1

• • Source

  • Amolops jingdongensis (Chinese torrent frog)

• • Family

  • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily

• • Gene

  • Not found

• • Sequence

  • FLPLFLPKIICVITKKC

• • Sequence Length

  • 17

• • UniProt Entry

  • K7ZGS2

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.22828809]Gram-negative bacterium: B.dysenteriae (MIC=35 μg/ml);
    • Gram-positive bacteria: S.aureus ATCC 2592 (MIC=4.7 μg/ml), B.subtilis ATCC 6633 (MIC=9.38 μg/ml);
    • Fungus: C.albicans (MIC=18.75 μg/ml)

• • Hemolytic Activity

  • • [Ref.22828809] It exhibits hemolysis of 1.32%, 5.37%, 6.35%, 16.55% at 25 μg/ml, 50 μg/ml, 100 μg/ml, 200 μg/ml against rabbit red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization(Cys11 and Cys17).

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys11 and Cys17.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18185.

DRAMP18185

• • Function

  • Has activity against Gram- negative bacterium and exhibits hemolytic activity.

• ·Literature 1

• • Title

  • Antimicrobial peptide diversity in the skin of the torrent frog,Amolops jingdongensis.

• • Pubmed ID

  • 22828809

• • Reference

  • Amino Acids 44:481-487(2013)

• • Author

  • He X., Yang S., Wei L., Liu R., Lai R., Rong M.