General Information

    • DRAMP ID

    • DRAMP18187

    • Peptide Name

    • Toxin LyeTx 1

    • Source

    • Lycosa erythrognatha (Spider) (Scaptocosa raptoria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IWLTALKFLGKNLGKHLAKQQLAKL

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19946788]Gram-positive bacterium: S.aureus (MIC=3.79 μM);
      • Gram-negative bacterium: E.coli (MIC=7.81 μM);
      • Yeasts: C.krusei (MIC=26.3 μM), C.neoformans (MIC=13.2 μM).

    • Hemolytic Activity

      • [Ref.19946788]ED50=1.3 × 10−4 M against rabbit erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18187 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP18187.

Physicochemical Information

    • Formula

    • C135H226N36O30

    • Absent Amino Acids

    • CDEMPRSVY

    • Common Amino Acids

    • L

    • Mass

    • 2833.5

    • PI

    • 10.6

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +6

    • Boman Index

    • -72

    • Hydrophobicity

    • 0.148

    • Aliphatic Index

    • 136.8

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 4

DRAMP18187

DRAMP18187 chydropathy plot

Comments Information

    • Function

    • Has hemolytic activity against rabbit erythrocytes. Forms pores in lipid bilayers in vitro; pore formation is reduced when cholesterol is present in the bilayers.

Literature Information

  • ·Literature 1

    • Title

    • LyeTx I, a potent antimicrobial peptide from the venom of the spiderLycosa erythrognatha.

    • Reference

    • Amino Acids 39:135-144(2010)

    • Author

    • Santos D.M., Verly R.M., Pilo-Veloso D., de Maria M.,de Carvalho M.A., Cisalpino P.S., Soares B.M., Diniz C.G.,Farias L.M., Moreira D.F., Frezard F., Bemquerer M.P., Pimenta A.M.,de Lima M.E.