General Information

    • DRAMP ID

    • DRAMP18188

    • Peptide Name

    • Pantinin-1 (Non-disulfide-bridged peptide 4.20, NDBP-4.20, Non-disulfide-bridged peptide 5.21, ND

    • Source

    • Pandinus imperator (Emperor scorpion)

    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short an

    • Gene

    • Not found

    • Sequence

    • GILGKLWEGFKSIV

    • Sequence Length

    • 14

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.23624072]Gram-positive bacteria: S.aureus (MIC=8 μM), B.magaterium (MIC=32 μM), M.luteus (MIC=32 μM ), VRE (MIC=28 μM), MRSA (MIC=14 μM);
      • Gram-negative bacteria: E.coli (MIC=62 μM), P.putida (MIC >87 μM), K.oxytoca (MIC >87 μM), E.cloacae (MIC=76 μM), S.enterica (MIC=72 μM);
      • Fungus: C.tropicalis (MIC=16 μM).

    • Hemolytic Activity

      • [Ref.23624072]0% hemolytic activity at 16 μM, 0% hemolytic activity at 32 μM, 20% hemolytic activity at 64 μM against human red bood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18188 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18188.

Physicochemical Information

    • Formula

    • C75H119N17O18

    • Absent Amino Acids

    • ACDHMNPQRTY

    • Common Amino Acids

    • G

    • Mass

    • 1546.87

    • PI

    • 8.59

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 1054

    • Hydrophobicity

    • 0.671

    • Aliphatic Index

    • 132.14

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 4

DRAMP18188

Comments Information

    • Function

    • Amphipathic peptide that possesses relatively strong activities against Gram-positive bacteria and a fungus, but has very weak antimicrobial activities against Gram-negative bacteria. Also exhibits very low hemolytic activities against human erythrocytes.Forms an alpha-helical membrane channel in the prey.

Literature Information

  • ·Literature 1

    • Title

    • Three new antimicrobial peptides from the scorpion Pandinusimperator.

    • Reference

    • Peptides 45:28-34(2013)

    • Author

    • Zeng X.C., Zhou L., Shi W., Luo X., Zhang L., Nie Y., Wang J., Wu S.,Cao B., Cao H.
  • ·Literature 2

    • Title

    • Scorpion venom peptides with no disulfide bridges: a review.

    • Reference

    • Peptides 51:35-45(2014

    • Author

    • Almaaytah A., Albalas Q.