General Information

    • DRAMP ID

    • DRAMP18191

    • Peptide Name

    • Antimicrobial peptide AcrAP1

    • Source

    • Androctonus crassicauda (Arabian fat-tailed scorpion)

    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short an

    • Gene

    • Not found

    • Sequence

    • FLFSLIPHAISGLISAFK

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-positive bacteria: S.aureus (MIC=8 uM, MBC=32 uM);
      • Yeast: C.albicans (MIC=16 uM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18191 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18191.

Physicochemical Information

    • Formula

    • C97H149N21O22

    • Absent Amino Acids

    • CDEMNQRTVWY

    • Common Amino Acids

    • FILS

    • Mass

    • 1961.38

    • PI

    • 8.76

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 2261

    • Hydrophobicity

    • 1.411

    • Aliphatic Index

    • 141.11

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP18191

DRAMP18191 chydropathy plot

Comments Information

    • Has antimicrobial activity against the Gram-positive bacteria S.aureus and the yeast C.albicans. Causes hemolysis on horse erythrocytes (64 uM for 100% hemolysis).

Literature Information

  • ·Literature 1

    • Title

    • Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1and AcrAP2, from the venom of the scorpion, Androctonus crassicauda,display potent growth modulation effects on human cancer cell lines.

    • Reference

    • Int. J. Biol. Sci. 10:1097-1107(2014)

    • Author

    • Du Q., Hou X., Ge L., Li R., Zhou M., Wang H., Wang L., Wei M.,Chen T., Shaw C.