General Information
-
DRAMP ID
- DRAMP18193
-
Peptide Name
- Cathelicidin-related peptide crotalicidin
-
Source
- Crotalus durissus terrificus (South American rattlesnake)
-
Family
- Belongs to the cathelicidin family.
-
Gene
- Not found
-
Sequence
- KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
-
Sequence Length
- 34
-
UniProt Entry
- U5KJM4
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.25100358]Gram-negative: E.coli ATCC 25922 (MIC=0.25 μg/mL),P.aeruginosa (MIC=1 μg/mL);
- Gram-positive: E.faecalis (MIC=32 μg/mL), S.aureus (MIC=32 μg/mL).
-
Hemolytic Activity
-
- [Ref.25100358]10% hemolytic activity at 12.5 µM against red blood cells
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Other Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- alpha helical
-
Structure Description
- Not found
-
PDB ID
- 2MWT resolved by NMR
-
-
-
2MWT-> 
-
Physicochemical Information
-
Formula
- C203H345N53O37S
Absent Amino Acids
- ACDEHNQWY
Common Amino Acids
- K
Mass
- 4152.37
PI
- 12.09
Basic Residues
- 15
Acidic Residues
- 0
Hydrophobic Residues
- 13
Net Charge
- +15
-
Boman Index
- -5393
Hydrophobicity
- -0.435
Aliphatic Index
- 80
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP18193

Comments Information
Function
- Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane (By similarity). Hemolytic activities have been observed on mammalian cells. Expressed by the venom gland.
Literature Information
- ·Literature 1
-
Title
- Vipericidins: a novel family of cathelicidin-related peptides fromthe venom gland of South American pit vipers.
-
Pubmed ID
- 25100358
-
Reference
- Amino Acids 46:2561-2571(2014)
-
Author
- Falcao C.B., de La Torre B.G., Perez-Peinado C., Barron A.E.,Andreu D., Radis-Baptista G.