General Information

    • DRAMP ID

    • DRAMP18194

    • Peptide Name

    • AAEL000598-PA

    • Source

    • Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

    • Family

    • Not found

    • Gene

    • CECD

    • Sequence

    • GGLKKLGKKLEGAGKRVFKASEKALPVVVGIKAIGK

    • Sequence Length

    • 36

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative (including drug-resistent):
        Target OrganismActivity
        E. coliMIC 2-4 ug/mL
        P. aeruginosaMIC 1-4 ug/mL
        A. baumanniiMIC 1-2 ug/mL
        K. pneunomiaeMIC 1-2 ug/mL
      • No antibacterial effects of the peptide were observed against different isolates of Gram-positive S. aureus, E. faecalis and E. faecium strains showing MIC values over 32. (Pubmed:
        Target OrganismActivity
        25162372)-

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • PDB ID

    • 2MMM resolved by NMR.

    • Predicted Structure

Physicochemical Information

    • Formula

    • C169H300N48O42

    • Absent Amino Acids

    • CDHMNQTWY

    • Common Amino Acids

    • K

    • Mass

    • 3676.54

    • PI

    • 10.54

    • Basic Residues

    • 10

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +8

    • Boman Index

    • -1941

    • Hydrophobicity

    • -0.022

    • Aliphatic Index

    • 108.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP18194

DRAMP18194 chydropathy plot

Comments Information

    • The anti-bacterial activity of Aedesin was found to be salt-resistant, indicating that it is active under physiological conditions encountered in body fluids characterized by ionic salt concentrations.

Literature Information

  • ·Literature 1

    • Title

    • Genome sequence of Aedes aegypti, a major arbovirus vector.

    • Reference

    • Science 316:1718-1723(2007).

    • Author

    • Nene V., Wortman J.R., Lawson D., et al.
  • ·Literature 2

    • Title

    • Aedesin: structure and antimicrobial activity against multidrugresistant bacterial strains.

    • Reference

    • PLoS ONE 9:e105441-e105441(2014).

    • Author

    • Godreuil S., Leban N., Padilla A., et al.