• DRAMP ID

    • DRAMP18196
    • Peptide Name

    • Esculentin-1A
    • Source

    • Pelophylax esculentus (Edible frog) (Rana esculenta)
    • Family

    • Belongs to the frog skin active peptide (FSAP) family
    • Gene

    • Unknow
    • Sequence

    • GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
    • Sequence Length

    • 46
    • Evidence code

    • Biological Activity

    • Antibacterial,Antibiotic
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • DRAMP18196 helical wheel diagram
    • Formula

    • C212H371N59O60S3
    • Absent Amino Acids

    • HPQWY
    • Common Amino Acids

    • GK
    • Mass

    • 560570
    • PI

    • 10.33
    • Basic Residues

    • 9
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 17
    • Boman Index

    • -2864
    • Hydrophobicity

    • 21.96
    • Aliphatic Index

    • 114.35
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 2.78
    • Polar Residues

    • 15

Amino Acid Distribution

DRAMP18196 chydropathy plot
    • Function

    • Antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
  • Literature 1
    • Reference

    • J. Biol. Chem. 269:11956-11961(1994)
    • Author

    • Simmaco M., Mignogna G., Barra D., Bossa F.
    • Title

    • Antimicrobial peptides from skin secretions of Rana esculenta.Molecular cloning of cDNAs encoding esculentin and brevinins andisolation of new active peptides.