General Information

    • DRAMP ID

    • DRAMP18204

    • Peptide Name

    • Labyrinthopeptin A1(Bacteriocin)

    • Source

    • Actinomadura namibiensis DSM 6313

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • labA1

    • Sequence

    • SNASVWECCSTGSWVPFTCC

    • Sequence Length

    • 20

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral, Anti-HIV, Anti-HSV

    • Target Organism

      • HSV(EC50: 0.29

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • LabyA1 contains a special amino acid labionin at positions 1, 4, 8, 10, 13, and 19. Labs 1,4 and labs 10, 13 are connected via a carbon-carbon bond, while labs 4, 8 and labs 13, 19 form normal thioether bonds. In addition, a disulfide bond occurs between C9 and C20.

    • Helical Wheel Diagram

    • DRAMP18204 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18204.

Physicochemical Information

    • Formula

    • C92H131N23O30S4

    • Absent Amino Acids

    • DHIKLMQRY

    • Common Amino Acids

    • CS

    • Mass

    • 2167.43

    • PI

    • 4

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -1

    • Boman Index

    • -860

    • Hydrophobicity

    • 0.38

    • Aliphatic Index

    • 34

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11250

    • Absorbance 280nm

    • 592.11

    • Polar Residues

    • 12

DRAMP18204

DRAMP18204 chydropathy plot

Comments Information

    • Function

    • LabyA1 also demonstrated additive to synergistic effects in its anti-HIV-1 and anti-HSV-2 activity with anti(retro)viral drugs in dual combinations such as tenofovir, acyclovir, saquinavir, raltegravir and enfuvirtide.

Literature Information

  • ·Literature 1

    • Title

    • The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications

    • Reference

    • PLoS One. 2013 May 28;8(5):e64010.

    • Author

    • F