General Information

    • DRAMP ID

    • DRAMP18205

    • Peptide Name

    • Labyrinthopeptin A2 (Bacteriocin)

    • Source

    • Actinomadura namibiensis DSM 6313

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • labA2

    • Sequence

    • SDWSLWECCSTGSLFACC

    • Sequence Length

    • 18

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

    • HSV

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • This peptide contains a special amino acid labionin at positions 1, 4, 8, 10, 13, and 17. Labs 1,4 and labs 10, 13 are connected via a carbon-carbon bond, while labs 4, 8 and labs 13, 17 form normal thioether bonds. In addition, a disulfide bond occurs between C9 and C18.

    • Helical Wheel Diagram

    • DRAMP18205 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18205.

Physicochemical Information

    • Formula

    • C85H120N20O28S4

    • Absent Amino Acids

    • HIKMNPQRVY

    • Common Amino Acids

    • CS

    • Mass

    • 1998.24

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -2

    • Boman Index

    • -635

    • Hydrophobicity

    • 0.506

    • Aliphatic Index

    • 48.89

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11250

    • Absorbance 280nm

    • 661.76

    • Polar Residues

    • 10

DRAMP18205

DRAMP18205 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification.

    • Reference

    • Angew Chem Int Ed Engl. 2010 Mar 22;49(13):2436-40.

    • Author

    • M