General Information

    • DRAMP ID

    • DRAMP18214

    • Peptide Name

    • Cerecidin A1(Bacteriocin)

    • Source

    • Bacillus cereus

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • TTPLCVGVIIGLTTSIKICK

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18214 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18214.

Physicochemical Information

    • Formula

    • C92H166N22O26S2

    • Absent Amino Acids

    • ADEFHMNQRWY

    • Common Amino Acids

    • IT

    • Mass

    • 2060.58

    • PI

    • 8.88

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 1726

    • Hydrophobicity

    • 1.26

    • Aliphatic Index

    • 146

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.58

    • Polar Residues

    • 9

DRAMP18214

DRAMP18214 chydropathy plot

Comments Information

    • Fuction

    • Active against multiple Gram-positive strains, B. cereus As 1.348, B. cereus As 1.352, B. thuringiensis 1.1013, B. thuringiensis 1.1014, B. subtilis 1.107, B. subtilis DB104, B. pumilus 1.1165, E. faecalis 1.14, E. faecalis V583, E. durans 1.2023, E. pernyi 1.1010, L. coprophilus 1.214, L. acidophilus 100-33, L. casei 1.575, L. rhamnosus 1.104, L. plantarum 1.551, L. brevis 1.2028, L. brevis 1.7, L. buchneri 1.40, L. lactis LM0230, L. lactis MG1363, L. curvatus LTH1.174, L. dextranicum 181 (zone inhibition 6-10 mm, M. flavus NCIB8166 (zone inhibition 15 mm), S. bovis LG42, S. gordonii 1.2496, S. salivarius 1.2498, and S. thermophilus 1.1864 (Zone inhibition 7-9 mm), including resistant superbugs (MRSA and VRE).

Literature Information

  • ·Literature 1

    • Title

    • Cerecidins, novel lantibiotics from Bacillus cereus with potent antimicrobial activity.

    • Reference

    • Appl Environ Microbiol. 2014 Apr;80(8):2633-43.

    • Author

    • Wang J, Zhang L, Teng K, Sun S, Sun Z, Zhong J.