General Information

    • DRAMP ID

    • DRAMP18218

    • Peptide Name

    • Fusaricidin A (Bacteriocin)

    • Source

    • Bacillus polymyxa KT-8

    • Family

    • Belongs to the lipopeptides family

    • Gene

    • Not found

    • Sequence

    • TVVTNA

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • The carboxylic end of Ala6 forms an ester bond with the hydroxyl group of T1. Val2, Asn5, Ala6 are D-amino acids and Thr4 is a D-allo-Thr. In addition, the N-terminus NH is lipidated with 15-guanidino-3-hydroxypentadecanoic acid (GHPD).

    • Helical Wheel Diagram

    • DRAMP18218 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18218.

Physicochemical Information

    • Formula

    • C25H45N7O10

    • Absent Amino Acids

    • CDEFGHIKLMPQRSWY

    • Common Amino Acids

    • TV

    • Mass

    • 603.67

    • PI

    • 5.19

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • -189

    • Hydrophobicity

    • 0.883

    • Aliphatic Index

    • 113.33

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18218

Comments Information

    • Fusaricidin A was elucidated to be a cyclic depsipeptide containing a unique fatty acid, 15-guanidino-3-hydroxypentadecanoic acid. Fusaricidins B, C, and D are minor components from the culture broth of a bacterial strain Bacillus polymyxa KT-8.

Literature Information

  • ·Literature 1

    • Title

    • Fusaricidin A, a new depsipeptide antibiotic produced by Bacillus polymyxa KT-8. Taxonomy, fermentation, isolation, structure elucidation and biological activity.

    • Reference

    • J Antibiot (Tokyo). 1996 Feb;49(2):129-35.

    • Author

    • Kajimura Y, Kaneda M.
  • ·Literature 2

    • Title

    • Prediction of the mechanism of action of fusaricidin on Bacillus subtilis.

    • Reference

    • PLoS One. 2012;7(11):e50003.

    • Author

    • Yu WB, Yin CY, Zhou Y, Ye BC.