General Information

    • DRAMP ID

    • DRAMP18222

    • Peptide Name

    • PseA(Bacteriocin)

    • Source

    • Bacillus pseudomycoides DSM 12442

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • GDCGGTCTWTKDCSICPSWSCWSWSC

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • This antibiotic with four thioether rings and a disulfide bond. The leader sequence shows highest (37%) similarity to the leader sequence of mersacidin.The N terminus of the corepeptide contains the conserved lipid II binding motif of class II lantibiotics (TxS/TxE/DC) and, interestingly, the C terminus of the core peptide contains two SWSC motifs. Such motifs also are found in the heterocycloanthracins.

    • Helical Wheel Diagram

    • DRAMP18222 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18222.

Physicochemical Information

    • Formula

    • C120H167N31O39S6

    • Absent Amino Acids

    • AEFHLMNQRVY

    • Common Amino Acids

    • C

    • Mass

    • 2860.19

    • PI

    • 4.21

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -1

    • Boman Index

    • -2296

    • Hydrophobicity

    • -0.15

    • Aliphatic Index

    • 15

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 22375

    • Absorbance 280nm

    • 895

    • Polar Residues

    • 17

DRAMP18222

DRAMP18222 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides.

    • Reference

    • Appl Environ Microbiol. 2015 May 15;81(10):3419-29.

    • Author

    • Basi-Chipalu S, Dischinger J, Josten M, Szekat C, Zweynert A, Sahl HG, Bierbaum G.