General Information
-
DRAMP ID
- DRAMP18233
-
Peptide Name
- Gageopeptide B(Bacteriocin)
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Source
- Bacillus subtilis
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Family
- Belongs to the lipopeptides family
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Gene
- Not found
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Sequence
- LLLE
-
Sequence Length
- 4
-
UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
- Gram-positive, Gram-negative
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Leu-Leu-Leu-OMeGlu-3-beta-hydroxy-12-methyltetradecanoic acid
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18233.
Physicochemical Information
-
Formula
- C23H42N4O7
Absent Amino Acids
- ACDFGHIKMNPQRSTVW
Common Amino Acids
- L
Mass
- 486.61
PI
- 4
Basic Residues
- 0
Acidic Residues
- 1
Hydrophobic Residues
- 3
Net Charge
- -1
-
Boman Index
- 795
Hydrophobicity
- 1.975
Aliphatic Index
- 292.5
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP18233
Comments Information
Non-cytotoxic antifungal agents. It was revealed that compounds 1 and 2 exhibited stronger antifungal activity than 3 and 4. Compounds 1 and 2 were structurally different from compounds 3 and 4 in terms of having less side chains in the fatty acid units, suggesting that the side chain length and the additional methyl group in the aliphatic chain are important for antifungal activity. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04?0.08 uM.
Literature Information
- ·Literature 1
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Title
- Study in cytotoxicity of gentamycin to corneal epithelium and endothelium in tissue culture.
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Pubmed ID
- 2485741
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Reference
- Yan Ke Xue Bao. 1989 Jun;5(1-2):32-5.
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Author
- Lin N, Gong XM, Xie QJ, Shao MR.