General Information

    • DRAMP ID

    • DRAMP18236

    • Peptide Name

    • NRWC(Bacteriocin)

    • Source

    • Bacillus subtilis ATCC 6633

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • NRWCFAGDD

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • The sequence showed no homology with other known antimicrobial peptides.

    • Helical Wheel Diagram

    • DRAMP18236 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18236.

Physicochemical Information

    • Formula

    • C46H62N14O15S

    • Absent Amino Acids

    • EHIKLMPQSTVY

    • Common Amino Acids

    • D

    • Mass

    • 1083.14

    • PI

    • 4.21

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 3

    • Net Charge

    • -1

    • Boman Index

    • -2966

    • Hydrophobicity

    • -1.022

    • Aliphatic Index

    • 11.11

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 687.5

    • Polar Residues

    • 3

DRAMP18236

Comments Information

    • The antimicrobial activity was affected by the action of the proteases pronase E and proteinase K, but the absence of the inhibition zone against H. parasuis was only observed when the enzymes were used at 10 mg/ml.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of an antimicrobial peptide produced by Bacillus subtilis subsp. spizezinii showing inhibitory activity towards Haemophilus parasuis.

    • Reference

    • Microbiology. 2013 May;159(Pt 5):980-8.

    • Author

    • Teixeira ML, Dalla Rosa A, Brandelli A.