General Information

    • DRAMP ID

    • DRAMP18264

    • Peptide Name

    • Enterocin W beta(Bacteriocin)

    • Source

    • Enterococcus faecalis NKR-4-1

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • VTTSIPCTVMVSAAVCPTLVCSNKCGGRG

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive (Narrow)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Enterocin Wbeta was proven to have 3 dehydrated amino acids as well as 2 and 2 Lan and MeLan residues, respectively. The amino acid sequences of the prepeptides of enterocin W showed the highest identity with those of plantaricins Walpha and Wbeta (63.3 and 44.7%, respectively).

    • Helical Wheel Diagram

    • DRAMP18264 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18264.

Physicochemical Information

    • Formula

    • C117H204N34O38S5

    • Absent Amino Acids

    • DEFHQWY

    • Common Amino Acids

    • V

    • Mass

    • 2855.41

    • PI

    • 8.54

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • -364

    • Hydrophobicity

    • 0.803

    • Aliphatic Index

    • 83.79

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 8.93

    • Polar Residues

    • 15

DRAMP18264

DRAMP18264 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterization of enterocin W, a novel two-peptide lantibiotic produced by Enterococcus faecalis NKR-4-1.

    • Reference

    • Appl Environ Microbiol. 2012 Feb;78(3):900-3.

    • Author

    • Sawa N, Wilaipun P, Kinoshita S, Zendo T, Leelawatcharamas V, Nakayama J, Sonomoto K.