General Information
-
DRAMP ID
- DRAMP18265
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Peptide Name
- Enterocin RM6 (Bacteriocin)
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Source
- Enterococcus faecalis OSY-RM6
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Family
- Belongs to the class IIc bacteriocin
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Gene
- Not found
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Sequence
- MAKEFGIPAAVAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW
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Sequence Length
- 70
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UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
- Gram-positive
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Tandem mass spectrometry (MS/MS) analysis revealed that enterocin RM6 is a 70-residue cyclic peptide with a head-to-tail linkage between methionine and tryptophan residues.
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Helical Wheel Diagram
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PDB ID
- 1E68
- 1E68-> 
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Predicted Structure
- Please click DRAMP18265_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C328H549N87O89S
Absent Amino Acids
- CDHQ
Common Amino Acids
- A
Mass
- 7167.56
PI
- 10.09
Basic Residues
- 10
Acidic Residues
- 4
Hydrophobic Residues
- 35
Net Charge
- +6
-
Boman Index
- -61
Hydrophobicity
- 0.539
Aliphatic Index
- 117.14
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 12490
Absorbance 280nm
- 181.01
Polar Residues
- 19
DRAMP18265
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Characterization and application of enterocin RM6, a bacteriocin from Enterococcus faecalis.
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Pubmed ID
- 23844357
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Reference
- Biomed Res Int. 2013;2013:206917.
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Author
- Huang E, Zhang L, Chung YK, Zheng Z, Yousef AE.