General Information

    • DRAMP ID

    • DRAMP18267

    • Peptide Name

    • BacFL31(Bacteriocin)

    • Source

    • Enterococcus faecium FL31

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • GLEESPGHPGQPGPPGPPGAPGP

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antilisterial

    • Target Organism

    • Gram-positive(certain)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Pro-rich

    • Structure Description

    • It is usual that even in the N-terminal 23 residues sequenced, six prolines at positions 6,9,12,15,18, and 21 are hydroxylated.

    • Helical Wheel Diagram

    • DRAMP18267 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C92H136N26O30

    • Absent Amino Acids

    • CDFIKMNRTVWY

    • Common Amino Acids

    • P

    • Mass

    • 2086.25

    • PI

    • 4.51

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • -1

    • Boman Index

    • -1391

    • Hydrophobicity

    • -1.135

    • Aliphatic Index

    • 21.3

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP18267

DRAMP18267 chydropathy plot

Comments Information

    • To our knowledge, BacFL31 is the first bacteriocin described as encompassing hydroxyproline residues. BacFL31 exerted bactericidal effect against L. monocytogenes and proved useful for the inhibition of the growth of L. monocytogenes in minced beef meat during storage at 4 Celsius degree.

Literature Information

  • ·Literature 1

    • Title

    • An antilisterial bacteriocin BacFL31 produced by Enterococcus faecium FL31 with a novel structure containing hydroxyproline residues.

    • Reference

    • Anaerobe. 2014 Jun;27:1-6.

    • Author

    • Chakchouk-Mtibaa A, Elleuch L, Smaoui S, Najah S, Sellem I, Abdelkafi S, Mellouli L.