General Information
-
DRAMP ID
- DRAMP18270
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Peptide Name
- Enterocin NKR-5-3Z(Bacteriocin)
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Source
- Enterococcus faecium NKR-5-3
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Family
- Belongs to the class IIb bacteriocin
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Gene
- enkZ
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Sequence
- KINWGSVGGSCVGGAVIGGALGGLGGAGGGCLTGAIGSIWDQW
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Sequence Length
- 43
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UniProt Entry
- I4DXG1
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
- Gram-positive
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Ent53A and Ent53Z, components of a class IIb bacteriocin, show synergistic antimicrobial activity.
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18270.
Physicochemical Information
-
Formula
- C172H267N49O52S2
Absent Amino Acids
- EFHMPRY
Common Amino Acids
- G
Mass
- 3917.43
PI
- 5.82
Basic Residues
- 1
Acidic Residues
- 1
Hydrophobic Residues
- 17
Net Charge
- 0
-
Boman Index
- 3917
Hydrophobicity
- 0.642
Aliphatic Index
- 93.02
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 16625
Absorbance 280nm
- 395.83
Polar Residues
- 23
DRAMP18270
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Gene cluster responsible for secretion of and immunity to multiple bacteriocins, the NKR-5-3 enterocins.
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Pubmed ID
- 25149515
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Reference
- Appl Environ Microbiol. 2014 Nov;80(21):6647-55.
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Author
- Ishibashi N, Himeno K, Masuda Y, Perez RH, Iwatani S, Zendo T, Wilaipun P, Leelawatcharamas V, Nakayama J, Sonomoto K.